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GHRP-6

Research Use Only
peptideSubcutaneous injection

A growth hormone booster that also seriously increases your appetite by mimicking ghrelin (your hunger hormone). Good for bulking phases or anyone who struggles to eat enough calories.

What to Expect

1

Week 1–2

Strong appetite increase within minutes of injection. Improved sleep quality. Cortisol and prolactin elevation possible. GH pulse after each injection.

2

Week 3–6

Enhanced recovery from training. Muscle fullness increasing. Fat loss may begin despite strong appetite. Improved skin quality.

3

Week 8+

Body recomposition benefits. Connective tissue repair. Sustained GH elevation. Less selective than Ipamorelin — more side effects.

Common Side Effects

Intense hunger (very common)Water retentionCortisol elevationProlactin increaseTingling/numbnessJoint pain
Tolerance: Moderate after 8-12 weeks — receptor desensitization possible
Cycling: 8-12 weeks on, 4-6 weeks off. Consider switching to Ipamorelin for cleaner GH release.

Dosing

100-300 mcg subq 2-3 times daily on an empty stomach. Cycle for 8-12 weeks.

Benefit Profile

💪 Muscle Growth
7/10
😴 Sleep
4/10
🩹 Injury Healing
4/10
🔥 Fat Loss
3/10

Medical Considerations

Medical oversight strongly recommendedNot safe during pregnancy

Contraindications

  • ✕Active cancer
  • ✕Diabetes (strong appetite stimulation)
  • ✕Obesity
  • ✕Pregnancy/nursing

Drug Interactions

Insulin and hypoglycemicsGlucocorticoidsSomatostatin analogs

Recommended Monitoring

  • →IGF-1 levels
  • →Fasting glucose
  • →Prolactin and cortisol levels
  • →Body weight

This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol.

Pricing

VendorVariantPrice
Skye Peptides5mg$24.99
Buy
Swiss Chems ⚠
FDA warning letter received late 2024
5mg$24.95
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Amino Asylum ⚠
Reported federal raid in 2025
5mg$19.99BEST
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Peptide Sciences ✕
Announced voluntary shutdown
5mg$29.00
Buy

Published Research

20 studies indexed(1993–2025)15 clinical trials2 reviews

Pharmacokinetic study of Growth Hormone-Releasing Peptide 6 (GHRP-6) in nine male healthy volunteers.

Cabrales A, Gil J, et al.·Eur J Pharm Sci·2013
Clinical Trial

Effects of ghrelin, GH-releasing peptide-6 (GHRP-6) and GHRH on GH, ACTH and cortisol release in hyperthyroidism before and after treatment.

Molica P, Nascif SO, et al.·Pituitary·2010
Clinical Trial

Effects of ghrelin, growth hormone-releasing peptide-6, and growth hormone-releasing hormone on growth hormone, adrenocorticotropic hormone, and cortisol release in type 1 diabetes mellitus.

de Sá LB, Nascif SO, et al.·Metabolism·2010
Clinical Trial

Decreased ghrelin-induced GH release in thyrotoxicosis: comparison with GH-releasing peptide-6 (GHRP-6) and GHRH.

Nascif SO, Correa-Silva SR, et al.·Pituitary·2007
Clinical Trial

GHRP-6 is able to stimulate cortisol and ACTH release in patients with Cushing's disease: comparison with DDAVP.

Oliveira JH, Vieira JG, et al.·J Endocrinol Invest·2003
Clinical Trial

Acute dexamethasone administration enhances GH responsiveness to GH releasing peptide-6 (GHRP-6) in man.

Pinto AC, Finamor FE Jr, Lengyel AM·Clin Endocrinol (Oxf)·1999
Clinical Trial

Effects of growth hormone-releasing peptide-6 on the nocturnal secretion of GH, ACTH and cortisol and on the sleep EEG in man: role of routes of administration.

Frieboes RM, Murck H, et al.·J Neuroendocrinol·1999
Clinical Trial

Growth hormone responses to GH-releasing peptide (GHRP-6) in hypothyroidism.

Pimentel-Filho FR, Ramos-Dias JC, et al.·Clin Endocrinol (Oxf)·1997
Clinical Trial

Interaction of the growth hormone releasing peptide hexarelin with somatostatin.

Massoud AF, Hindmarsh PC, Brook CG·Clin Endocrinol (Oxf)·1997
Clinical Trial

Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature.

Pihoker C, Badger TM, et al.·J Endocrinol·1997
Clinical Trial
Showing 10 of 20 studies. Search PubMed for the complete list.