A longevity peptide based on a compound from the pineal gland. It turns on the enzyme that protects the caps on your DNA (telomerase) and restores healthy melatonin production for better sleep. Russian studies showed a 25-33% lifespan increase in animals and reduced death rates in elderly patients. A 162-patient trial found no serious side effects, and sleep improvements typically show up within 1-2 weeks.
What to Expect
Week 1–2
Improved sleep onset and quality via melatonin modulation. Subtle increase in overall energy. No dramatic changes expected — mechanism is gradual.
Week 3–6
Better circadian rhythm regulation. Improved skin appearance. Possible mild improvements in visual acuity. Telomerase activation occurring at cellular level.
Week 8+
Cumulative anti-aging effects. Improved antioxidant status. Enhanced melatonin production. Full telomere-lengthening benefits require repeated cycles over years.
Common Side Effects
Scientific Overview
Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide based on Epithalamin, a polypeptide extract of bovine pineal gland. Its primary mechanism involves activation of telomerase (hTERT) in human somatic cells, extending telomere length and potentially increasing replicative capacity. A clinical study in 162 elderly patients demonstrated reduced cardiovascular mortality over 6 years of follow-up. Epithalon also modulates melatonin secretion by the pineal gland and influences circadian rhythm regulation through effects on the suprachiasmatic nucleus.
Dosing
Two approaches: 3 mg oral daily on an ongoing basis, OR 5-10 mg subq daily for 10-20 days as a "pulse" done twice a year. The continuous low-dose oral route may be better for long-term DNA cap (telomere) support.
Practical Guide
Reconstitution
Mix 10mg vial with 1-2mL BAC water. Typical dose is 5-10mg per injection.
Storage
Refrigerate after reconstitution. Use within 21 days. Store lyophilized powder at room temperature.
Injection Sites
Subcutaneous with insulin syringe. Short intensive cycles — daily injections for 10-20 days.
Timing
Evening injection may synergize with melatonin-enhancing effects. Consistent daily timing during cycle.
Food
No significant food interactions.
Benefit Profile
Medical Considerations
Contraindications
- ✕Active cancer (theoretical concern with telomerase activation)
- ✕Pregnancy/nursing
Drug Interactions
Recommended Monitoring
- →Telomere length testing (optional, before and after cycles)
- →Melatonin levels if sleep disturbance occurs
This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol.
Pricing
Published Research
Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up.
Effect of peptide preparation epithalamin on circadian rhythm of epiphyseal melatonin-producing function in elderly people.
Peptides of pineal gland and thymus prolong human life.
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.
[Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].
[Morphofunctional and molecular bases of pineal gland aging].
[Characteristics of the pineal gland and thymus relationship in aging].
[Influence of peptides from pineal gland on thymus function at aging].