A fragment of a natural immune protein that helps your body repair tissue, reduce inflammation, and grow new blood vessels. It works throughout your whole body, making it excellent for recovering from injuries of all kinds.
What to Expect
Week 1–2
Subtle reduction in systemic inflammation. Injury sites may feel slightly less stiff. Loading dose period — effects are accumulating.
Week 3–6
Improved flexibility and range of motion at injury sites. Hair growth may increase. Visible wound healing acceleration. Reduced swelling in chronic injuries.
Week 8+
Significant tissue remodeling and repair. New blood vessel formation in previously poorly-vascularized injuries. Sustained anti-inflammatory benefits.
Common Side Effects
Scientific Overview
Thymosin Beta-4 is a 43-amino acid polypeptide that sequesters G-actin monomers, regulating actin polymerization critical to cell migration, wound healing, and tissue remodeling. TB-500 promotes angiogenesis through upregulation of VEGF and activation of endothelial progenitor cells. Its anti-inflammatory properties stem from inhibition of NF-κB signaling and reduction of pro-inflammatory cytokines (IL-1β, TNF-α). The peptide crosses the blood-brain barrier and has demonstrated neuroprotective properties in traumatic brain injury models.
Dosing
Loading phase: 2-5 mg subq twice a week for 4 weeks. Then drop to 2 mg twice a week for maintenance.
Practical Guide
Reconstitution
Mix 5mg vial with 1-2mL BAC water. Each 0.1mL = 250-500mcg depending on dilution.
Storage
Refrigerate after reconstitution. Use within 30 days. Lyophilized powder stable at room temperature.
Injection Sites
TB-500 is systemic — injection site does not need to be near injury. Use 29-31g insulin syringe. Subcutaneous injection preferred.
Timing
Inject in the morning or evening — timing is flexible. During loading phase, space doses evenly (e.g., Monday/Thursday).
Food
No food interactions.
Benefit Profile
Medical Considerations
Contraindications
- ✕Active cancer (promotes angiogenesis)
- ✕Pregnancy/nursing
- ✕Active deep vein thrombosis
Drug Interactions
Recommended Monitoring
- →Monitor for unusual tissue growth
- →CBC if using long-term
This information is for educational purposes only. Always consult a qualified healthcare provider before starting any peptide protocol.
Published Research
Thymosin β(4) and β(10) Expression in Human Organs during Development: A Review.
Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.
Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies.
Thymosin beta 4 regulation of actin in sepsis.
Thymosin beta 4 and the eye: the journey from bench to bedside.
Sources of variability in quantifying circulating thymosin beta-4: literature review and recommendations.
Thymosin Beta 4 Is a Potential Regulator of Hepatic Stellate Cells.
Cardioprotection by Thymosin Beta 4.
Thymosin Beta 4: A Potential Novel Therapy for Neurotrophic Keratopathy, Dry Eye, and Ocular Surface Diseases.
Potential role of thymosin Beta 4 in liver fibrosis.